Ivabradine is well tolerated.

The most common adverse reactions with ivabradine, luminous phenomena (phosphenes) and bradycardia, are dose-dependent and related to the pharmacological effect of the medicinal product.¹

Patients with an adverse event, leading to withdrawal
	Ivabradine N=3232, n (%)	Placebo  N=3260, n (%)	P value
All adverse events	467 (14%)	416 (13%)	0.051
Symptomatic bradycardia	20 (1%)	5 (<1%)	0.002
Asymptomatic bradycardia	28 (1%)	5 (<1%)	<0.0001
Atrial fibrillation	135 (4%)	113 (3%)	0.137
Phosphenes	7 (<1%)	3 (<1%)	0.224
Blurred vision	1 (<1%)	1 (<1%)	1.000

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1. Swedberg K, et al. Lancet. 2010;376(9744):875-885.