Ivabradine reverses ventricular remodeling.
Significant improvement with ivabradine in left ventricular ejection fraction.¹

Ivabradine or placebo on top of guideline-recommended therapy including
ACE inhibitor, β-blocker, mineralocorticoi receptor antagonist.


1. Tardif JC, et al. Eur Heart J. 2011;32(20):2507-2515.

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on the importance of cardiac remodeling

  • Cardiac remodeling is central to the pathophysiology of heart failure and is a prognostic factor in patients with heart failure
  • Left ventricular enlargement and reduced ejection fraction are powerful predictors of outcomes in heart failure
  • Therapeutic effects of drugs and devices on left ventricular remodeling are associated with their longer-term effects on mortality