Ivabradine’s clinical benefits in chronic heart failure are maintained with or without renal dysfunction1


1. Voors AA, et al. Eur J Heart Fail. 2014;16(4):426-434.

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on ivabradine and renal function

Patients with heart failure commonly have renal dysfunction, which is one of the strongest predictors of mortality in these patients. It has been shown that treatment with ivabradine in patients with chronic heart failure, in sinus rhythm, with heart rate ≥70 bpm, did not affect renal function and all outcomes were improved in patients with renal dysfunction (eGFR <60 mL/min/1.73 m2) or without renal dysfunction: reduction in cardiovascular death or hospital admission for worsening heart failure, reduction in death from heart failure, reduction in recurrent hospitalization for heart failure.1