Ivabradine prolongs diastolic time by selectively and specifically inhibiting the If current, reducing heart rate.

Ivabradine increases stroke volume, fully preserves myocardial contractility and relaxation, atrioventricular conduction, and ventricular repolarization, as well as blood pressure.1-2

  1. Procoralan Summary of Product Characteristics. (EUROPE – latest update of January 2015)
  2. Deedwania P. Drugs. 2013;73(14):1569-1586.