Published in February 2014
Patients with heart failure commonly have renal dysfunction, which is one of the strongest predictors of mortality in these patients. It has been shown that treatment with ivabradine in patients with chronic heart failure, in sinus rhythm, with heart rate ≥70 beats/minute, did not affect renal function and all outcomes were improved in patients with renal dysfunction (eGFR <60 mL/min/1.73 m2) or without renal dysfunction: reduction in cardiovascular death or hospital admission for worsening heart failure, reduction in death from heart failure, reduction in recurrent hospitalization for heart failure.1

1. Voors AA, et al; SHIFT Investigators. The effect of heart rate reduction with ivabradine on renal function in patients with chronic heart failure: an analysis from SHIFT. Eur J Heart Fail. 2014 Feb 7. [Epub ahead of print]